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KMID : 0385219970070010040
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Korean Journal of Gerontology
1997 Volume.7 No. 1 p.40 ~ p.44
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Oxygen-derived free radicals and osteoclast differentiation
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Kang Jang-Sook
Ko Kun-Il
Park Rae-Kil
Kim Hyung-Ryong
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Abstract
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Osteotropic hormones and cytokines are involved in the differentiation of osteoclastic progenitors from hematopoietic stem cells to multinucleated osteoclasts. Recent studies have indicated that oxygen-derived free radicals are implicated in osteoclastic bone resorption. We tested whether superoxide dismutase (SOD), catalase, or hydrogen peroxide induce the generation of osteoclast-like multinucleated cells (MNCs). Both SOD and hydrogen peroxide augmented the ability of 1α,25-(OH)2D3 to induce the generation of osteoclast-like MNCs, but catalase was inhibitory. However, SOD, catalase, or hydrogen peroxide could not increase the generation of osteoclast-like MNCs. These data suggest that oxygen-derived free radicals are involved in the regulation of osteoclast generation.
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KEYWORD
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Superoxide dismutase, Catalase, Hydrogen Peroxide, Osteoclast generation
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